Academic
Particulars
- Assistant Professor, Joined UCB Faculty in 2004
- Departmental Area: Behavioral Neuroscience
- Ph.D. in Physiology & Psychology from the University of Washington in Seattle in 1993
- Post-doctoral Fellow, then Research Associate at the Center for Neurobiology & Behavior at Columbia University
- contact information
Research
Interests
The role of growth factors in altering the functional strength and structure of connections between nerve cells in the brain during normal learning and memory; perturbations of growth factor signaling in neurodegenerative and psychiatric disorders.
Selected
Publications
S. L. Patterson, L. M. Grover, P. A. Schwartzkroin and M. Bothwell. Activity dependent changes in neurotrophin expression in rat hippocampal slices - induction of LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9:1081-1088, 1992.
S. L. Patterson, T. Abel, T. A. S. Deuel, K. C. Martin, J. C. Rose and E. R. Kandel. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16:1137-1145, 1996.
C. T. Drake, T. A. Milner, and S. L. Patterson. Ultrastructural localization of full-length TrkB immunoreactivity in rat hippocampus suggests multiple roles in modulating activity-dependent synaptic plasticity. J. Neuroscience 19(18):8009-8026, 1999.
S. L. Patterson, C. Pittenger, A. Morozov, K. C. Martin, H. Scanlin, C. T. Drake and E. R. Kandel. Some forms of cAMP-mediated long lasting potentiation are associated with release of BDNF and nuclear translocation of MAP kinase. Neuron 32:123-140, 2001.
S. S. Zakharenko, S. L Patterson, I. Dragatsis, S. O. Zeitlin, S. A. Siegelbaum, E. R. Kandel, A. Morozov. Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses. Neuron 39: 975-990, 2003.
A. Barco, S.L. Patterson*, J.M. Alarcon*, A. Morozov and E. R. Kandel. Analysis of the mechanism of facilitated induction of L-LTP in VP16-CREB mice using whole-transcriptome profiling reveals the importance of BDNF for both the maintenance of LTP and for synaptic capture. Neuron. 48: 123-137, 2005. *Authors contributed equally to the work.
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