Publications of the Maier/Watkins Laboratory (last 5 years only)

Books and chapters in edited volumes Milligan, E.D., Maier, S.F., Watkins, L.R., Gene therapy in the central nervous system: chronic pain, Encyclopedia of Pain, 2009, in press. Maier, S. F., Amat, J., Baratta, M. V., Bland, S. T., Christianson, J. C., Thompson, B., Rozeske, R. R., & Watkins, L. R. The role of the medial prefrontal cortex in mediating resistance and vulnerability to the impact of adverse events. In C. M. Pariente, R. M. Nesse, D. Nutt, & L. Wolpert (Eds.), Understanding depression:a translational approach, Oxford University Press, 2009, 157-171. Milligan, E.D., Maier, S.F., Watkins, L.R., Gene therapy in the central nervous system: chronic pain, Encyclopedia, 2008, in press. Hutchinson, M.R., Johnson, K.W. & Watkins, L.R., Glial dysregulation of pain and opioid actions: past, present and future, Pain 2008 – An Updated Review, Castro-Lopes, J.M., Raja, S., and Schmelz, M. (Eds), IASP Press, Seattle, 2008. DeLeo, J.A., Sorkin, L. & Watkins, L.R. (Eds.), Immune and Glial Regulation of Pain, Seattle: International Association for the Study of Pain Press, (2007). Milligan, E.D., Ledeboer, A., Sloane, E.M., Busha, D.A. Maier, S.F. & Watkins, L.R., Glially driven enhancement of pain and its control by anti-inflammatory cytokines. In: DeLeo, J.A., Sorkin, L.S. & Watkins, L.R. (Eds), Immune and Glial Regulation of Pain, Seattle: IASP Press, 2007, pp. 319-340. Shavit, Y., Wolf, G., Johnston, I.N., Westbrook, R.F., Watkins, L.R. & Yirmiya, R., Proinflammatory cytokines modulate neuropathic pain, opioid analgesia, and opioid tolerance. In: DeLeo, J.A., Sorkin, L.S. & Watkins, L.R. (Eds), Immune and Glial Regulation of Pain, Seattle: IASP Press, 2007, 361-384. Ledeboer A, Sloane EM, Milligan ED, Langer SJ, Maier SF, Johnson KW, Leinwand LA, Chavez RA, Watkins LR. Paclitaxel-induced mechanical allodynia in rats is inhibited by spinal delivery of plasmid DNA encoding interleukin-10. In: Flor H, Kalso E, Dostrovsky JO (Eds), Proceedings of the 11th World Congress on Pain, Progress in Pain Research and Management, Seattle: IASP Press, 2007, pp. 187-194. Watkins, L.R., Milligan E.D. & Maier, S.F., Mechanisms of glial activation after nerve injury, Handbook of the Senses, Bushnell, C & Basbaum, A. (Eds)., Elsevier Press (2007) CD Rom. Wieseler-Frank, J., Milligan, E.D., Maier, S.F. & Watkins, L.R., Cord glial activation, Encyclopedic Reference of Pain, Schmidt, R. & Willis, W.D. (Ed.) Springer-Verlag, (2007) CD-Rom. Watkins, L.R. & Maier, S.F. Proinflammatory cytokines, Encyclopedic Reference of Pain, Schmidt, R. & Willis, W.D. (Ed.) Springer-Verlag, (2007) CD-Rom. Milligan, E.D., Maier, S.F.& Watkins, L.R., Inflammatory neuropathy, Encyclopedic Reference of Pain, Schmidt, R. & Willis, W.D. (Ed.) Springer-Verlag, (2007) CD-Rom.   Review Articles Watkins, L.R., Hutchinson, M.R., Rice, K., & Maier, S.F., The “toll” of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia, Trends in Pharmacological Sciences, (2009) in press. Maier, S.F. & Watkins, L.R., Role of the medial prefrontal cortex in coping and resilience, Brain Research Special Issue, (2009) in press. Sloane, E., Soderquist, R., Maier, S.F., Mahoney, M., Chavez, R., Watkins, L.R. & Milligan, E.D., Long term control of neuropathic pain in a non-viral gene therapy paradigm, Gene Therapy special issue (2009) in press. Milligan, E.D. and Watkins, L.R., Pathological and protective roles of glia in chronic pain, Nature Neuroscience Reviews, 10 (2009) 23-36. Milligan, E.D., Sloane, E. and Watkins, L.R., A role for the chemokine, fractalkine, in pathological pain states, Journal of NeuroImmunology, 198 (2008) 113-120. Hutchinson, M.R., Bland, S.T., Johnson, K.W., Rice, K.C., Maier, S.F. & Watkins, L.R., Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward, TheScientificWorldJOURNAL 7 (2007) 98-111. Ledeboer, A., Hutchinson, M.R., Watkins, L.R. & Johnson, K.W., AV411 (ibudilast): a new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes, Expert Opinion on Investigational Drugs, 16 (2007) 935-950. Watkins, L.R., Hutchinson, M.R., Milligan, E.D. & Maier, S.F., “Listening” and “talking” to neurons: implications of immune activation for clinical pain control and increasing the efficacy of opioids, Brain Research Reviews, 56 (2007) 148-169. Watkins, L.R., Hutchinson, M.R., Ledeboer, A., Wieseler-Frank, J., Milligan, E.D. & Maier, S.F., Glia as the “bad guys”: implications for improving clinical pain control and the clinical utility of opioids, Brain, Behavior & Immunity, 21 (2007) 131-146. Ledeboer, A., Hutchinson, M.R., Watkins, L.R. & Johnson, K.W., AV411 (ibudilast): a new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes, Expert Opinion on Investigational Drugs, (2007) in press. Watkins, L.R., Hutchinson, M.R., Milligan, E.D. & Maier, S.F., "Listening" and "talking" to neurons: implications of immune activation for clinical pain control and increasing the efficacy of opioids, Invited review for Neuron, (2007) in revision. Watkins, L.R., Hutchinson, M.R., Ledeboer, A., Wieseler-Frank, J., Milligan, E.D. & Maier, S.F., Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids, Brain, Behavior & Immunity, 21 (2007) 131-146. Maier. S. F., Amat, J., Baratta, M. V., & Watkins, L. R. Behavioral control, the medial prefrontal cortex, and resilience. Discourses in Clinical Neuroscience, 8 (2006) 397-407. Watkins, L.R., Hutchinson, M.R. Johnston, I. & Maier, S.F., Glia: Novel counter-regulators of opioid analgesia, Trends in Neuroscience 28 (2005) 661-669. Watkins, L.R. & Maier, S.F., Immune regluation of central nervous system functions: from sickness responses to pathological pain, Journal of Internal Medicine special volume for the Nobel Conference "The Inflammatory Reflex", 257 (2005) 139-155. Wieseler-Frank, J., Maier, S.F. & Watkins, L.R., Central proinflammatory cytokines and pain enhancement, NeuroSignals 14 (2005) 166-174. Wieseler-Frank, J., Maier, S.F. & Watkins, L.R., Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences, Brain, Behavior & Immunity, 19 (2005) 104-111. Maier, S. F. & Watkins, L. R. Stressor controllability and learned helplessness:The roles of the dorsal raphe nucleus, serotonin, and corticotropin releasing hormone. Neuroscience and Biobehavioral Reviews, 29 (2005) 829-841. Watkins, L.R. & Maier, S.F., Targeting glia to control clinical pain: An idea whose time has come, Drug Discovery Today: Therapeutic Strategies, 1 (2004) 83-88. Watkins, L.R. & Maier, S.F., Neuropathic pain: the immune connection, Clinical Updates, 12 (2004) 1-4. Wieseler-Frank, J., Milligan, E.D., Maier, S.F. & Watkins, L.R., Glial activation and pathological pain, Neurochemistry International, 45 (2004) 389-395. Watkins, L.R., Milligan, E.D. & Maier, S.F., Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain, Adv. Exp. Med. Biol.: Immune Mechanisms of Pain & Analgesia, 532 (2003) 1-21. Milligan, E.D., Maier, S.F. & Watkins, L.R., Neuronal-glial interactions in central sensitization, Seminars in Pain Medicine: Central Sensitization, 3 (2003) 171-183. Watkins, L.R. & Maier, S.F., Glia: a novel drug discovery target for clinical pain, Nature Reviews-Drug Discovery, 2 (2003) 973-985. Watkins, L.R. & Maier, S.F., When good pain turns bad, Current Directions in Psychological Sciences, 12 (2003) 232-236. Dworkin, R.H., Backonja, M., Rowbotham, M.C., Allen, R.R., Argoff, C.R., Bennett, G.J., Bushnell, C., Farrar, J.T., Galer, B.S., Haythornthwaite, J.A., Dewitt, D.J., Loeser, J.D., Max, M.B., Saltarelli, M., Schmader, K.E., Stein, C., Thompson, D., Turk, D.C., Wallace, M.S., Watkins, L.R., & Weinstein, S.M., Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations, Archives of Neurology, 60 (2003) 1524-1534. Maier, S. F. & Watkins, L. R. Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment. Brain, Behavior, and Immunity, 17 (2003) S125-S132. Watkins, L.R. & Maier, S.F., Beyond neurons: Evidence that immune and glial cells contribute to pathological pain states, Physiological Reviews, 82 (2002) 981-1011. Journal Articles Loram, L., Harrison, J., Sloane, E., Hutchinson, M., Sholar, P., Taylor, R., Berkelhammer, D., Coats, B., Poole, S., Milligan, E., Maier, S., Rieger, J., & Watkins, L.R., Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain, Journal of Neuroscience, (2009) in press. Christianson, J.P., Ragole, T., Amat, J., Greenwood, B.N., Strong, P.V., Paul, E.D., Fleshner, M., Watkins, L.R. & Maier, S.F., 5-hydroxytrapamine 2C receptors in the basolateral amgycala are involved in the expression of anxiety after uncontrollable traumatic stress, Biological Psychiatry (2009) in press. Sloane, E., Langer, S., Jekich, B., Mahoney, J., Hughes, T., Seibert, W., Huberty, G., Coats, B., Harrison, J., Klinman, D., Poole, S., Maier, S., Johnson, K.W., Chavez, R., Watkins, L.R., Leinwand, L., Milligan, E.D., Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain, Gene Therapy, (2009) in press. Barrientos, R.M., Watkins, L.R., Rudy, J.W. & Maier, S.F., Characterization of the sickness response in young and aging rats following E. coli infection, Brain, Behavior & Immunity, (2009) in press. Bilbo, S., Wieseler, J., Barrientos, R., Tsang, V., Watkins, L.R. & Maier, S.F., Neonatal bacterial infection alters fever to live and simulated infections in adulthood, Psychoneuroendocrinology (2009) in press. Wieseler, J., Ellis, A., Sprunger, D., Mahoney, J., Maier, S.F., & Watkins, L.R., A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats, Journal of Neuroscience Methods, (2009) in press. Baratta, M.V., Zarza, C.M., Gomez, D.M., Campeau, S., Watkins, L.R. & Maier, S.F., Selective activation of dorsal raphe nucleus-projecting neurons in the ventral medial prefrontal cortex by controllable stress, European Journal of Neuroscience (2009) in press. Hutchinson, M.R., Zhang, Y., Shridhar, M., Evans, J., Slivka, P.F., Buchanan, M.M., Zhao, T.X., Rezvani, N., Wieseler, J., Hughes, T.S., Falke, J.J., Leinwand, L.A., Maier, S.F., Yin, H., Rice, K.C. & Watkins, L.R., Evidence that opioids may have toll like receptor 4 and MD-2 effects, Brain, Behavior & Immunity (2009) in press. Bland, S.T., Hutchinson, M.R., Maier, S.F., Watkins, L.R. & Johnson, K.W., The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release, Brain, Behavior & Immunity (2009) in press. Hughes, T.S., Langer, S.J., Virtanen, S., Chavez, R.A., Watkins, L.R., Milligan, E.D. & Leinwand, L.A., Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression, Journal of Gene Medicine, (2009) in press. Rodgers, K.M., Hutchinson, M.R., Northcutt, A., Maier, S.F., Watkins, L.R. & Barth, D.S., The innate immune response of cortical glial cells increases neuronal excitability leading to seizures, Brain, (2009) in press. Soderquist, R.G., Milligan, E.D., Sloane, E.M., Harrison, J.A., Douvas, K.K., Potter, J.M., Hughes, T.S., Watkins, L.R. & Mahoney, M.J., PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced intrathecal delivery, Journal of Biomedical Materials Research, (2009) in press. Soderquist, R.G., Miligan, E.D., Harrison, J.A., Chavez, R.A., Johnson, K.W., Watkins, L.R. & Mahoney, M.J. PEGylation of interleukin-10 for the mitigation of enhanced pain states, Experimental Neurology, (2009) in press. Lewis, S.S., Hutchinson, M.R., Rezvani, N., Zhang, Y., Maier, S.F., Rice, K.C., Watkins, L.R., Morphine-3-glucuronide cuases enhance pain through pro-inflammatory glial mechanisms, Neuroscience (2009), in press. Hutchinson, M.R., Ramos, K., Loram, L., Wieseler, J., Lewis, M., Crysdale, N., Sholar, P.W., Kearney, J.J., Zhang, Y., Harrison, J., Maier, S.F., Rice, K.C. & Watkins, L.R., Evidence for a role of heat shock protein-90 (HSP90) in TLR4 mediated pain enhancement, Neuroscience. (2009) in press. Slivka, P.F., Shridhar, M., Lee, Gui-in, Sammond, D.W., Hutchinson, M.R., Martinko, A.J., Buchanan, M.M., Sholar, P.W., Kearney, J.J., Harrison, J.A., Watkins, L.R. & Ying, H., A peptide antagonist of the TLR4/MD2 interaction, ChemBioChem, 10 (2009) 645-649. Hughes, T.S., Langer, S.J., Johnson, K.W., Chavez, R., Milligan, E.D., Watkins, L.R.,& Leinwand, L.A., Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins, Molecular Therapy 17 (2009) 88-94. Christianson, J. P., Thompson, B., Watkins, L. R., & Maier, S. F., Medial prefrontal cortical activation modulates the impact of controllable and uncontrollable stressor exposure on a social exploration test of anxiety, Stress, Stress, 12 (2009) 445-450. Rozeske, R.R., Der-Avakian, A., Bland, S.T., Beckley, J.T., Watkins, L.R. & Maier, S.F., The medial prefrontal cortex regulates the differential expression of morphine conditioned place preference following a single exposure to controllable or uncontrollable stress Neuropsychopharmacology 34 (2009) 834-43. Christianson, J.P., Benison, A., Amat, J., Baratta, M., Paul, E., Kaufamn, R., Watkins, L.R., Campeau, S., Barth, D., Maier, S.F., The sensory insular cortex mediates the stress-buffering effects of safety signals but not behavioral control, Journal of Neuroscience 18 (2008) 13703-13711. Christianson, J.P., Paul, E.D. Irani, M., Thompson, B.M., Hubala, K.H., Yirmiya, R., Watkins, L.R., Maier, S.F., The role of prior stressor controllability and the dorsal raphe nucleus in sucrose preference and social exploration, Behavioral Brain Research (2008) in press. Sloane, E., Ledeboer, A., Seibert, W., Coats, B., VanStrien, M., Maier, S.F., Johnson, K.W., Chavez, R. Watkins, L.R., Leinwand, L., Milligan, E.D., VanDam, A.M., Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental multiple sclerosis, Brain, Behavior & Immunity, 23 (2008) 92-100. Hutchinson, M.R., Lewis, S.S., Coats, B.D., Skyba, D.A., Cysdale, N.Y., Berkelhammer, D.L., Brzeski, A., Northcutt, A., Vietz, C.M., Judd, C.M., Maier, S.F., Watkins, L.R. & Johnson, K.W., Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast), Brain, Behavior & Immunity, 23 (2008) 240-250. Barrientos, R.M. Frank, M.G., Hein, A.M, Higgins, E.A., Watkins, L.R., Rudy, J.W. & Maier, S.F., Timecourse of hippocampal interleukin-1beta and memory impairments in aging rats following peripheral infection, Brain Behav. Immun. 23 (2008) 46-54. Hutchinson, M.R., Zhang, Y., Brown, K., Coats, B.D., Shridhar, M., Sholar, P.W., Patel, S.J., Crysdale, N.Y., Maier, S.F., Rice, K.C. & Watkins, L.R., Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4), European Journal of Neuroscience 28 (2008) 20-29. Hutchinson, M.R., Coats, B.D., Lewis, S.S., Sprunger, D.B., Baker, E.M., Somogyi, A.A., Martin, D., Poole, S., Judd, C.M., Maier, S.F. & Watkins, L.R., Proinflammatory cytokines oppose opioid induced acute and chronic analgesia, Brain, Behavior & Immunity 22 (2008) 1178-1189. Rozeske, R.R., Der-Avakian, A., Bland, S.T., Beckley, J.T., Watkins, L.R. & Maier, S.F., The medial prefrontal cortex regulates the differential expression of morphine conditioned place preference following a single exposure to controllable or uncontrollable stress, Neuropsychopharmacology (2008) in press. Hughes, T.S., Langer, S.J., Johnson, K.W., Chavez, R., Milligan, E.D., Watkins, L.R.,& Leinwand, L.A., Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins, Molecular Therapy (2008) in press. Baratta, M. V., Lucero, T. R., Amat, J. Watkins, L. R., & Maier, S. F., Role of the ventral medial prefrontal cortex in mediating behavioral control-induced resistance to later fear conditioning. Learning and Memory, 15 (2008) 84-87. Hutchinson, M.R., Northcutt, A., Chao, L.W., Loram, L.C., Rozeske, R.R., Bland, S.T., Maier, S.F., Gleeson, T.T. & Watkins, L.R., Minocycline, a microglial inhibitor, suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia, Brain, Behavior & Immunity 22 (2008) 1248-1256. Amat, J., Paul, E., Watkins, L.R. & Maier, S.F., Activation of the ventral medial prefrontal cortex during an uncontrollable stressor reproduces both the immediate and long-term protective effects of behavioral control, Neuroscience 154 (2008) 1178-1186. Bilbo, S. Amat, J., Paul, E., Watkins, L.R, Yirmiya, R., Maier, S.F., Bacterial infection earily in life protects against stressor-induced depressive-like symptoms in adult rats, Psychoneuroendocrinology, 33 (2008) 261-269. Hein, A.M., Stutzman, D.L., Bland, S.T., Barrientos, R.M., Watkins, L.R., Rudy, J.W. & Maier, S.F., Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1beta injections into the dorsal hippocampus, Neuroscience, 150 (2007) 754-763. Bilbo, S., Barrientos, R., Eads, A., Northcutt, A., Rudy, J.W., Watkins, L.R. & Maier, S.F., Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood, Brain, Behavior & Immunity, 22 (2007) 451-455. Hein, A., Barrientos, R., Bland, S., Stutzman, D., Watkins, L.R., Rudy, J., & Maier, S.F., Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus, Neuroscience, 150 (2007) 754-763. Bland, S.T., Tamlyn, J.P., Barrientos, R.M., Greenwood, B.N., Watkins, L.R., Campeau, S., Hay, H.E. & Maier, S.F., Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or controllable stress, Neuroscience, 144 (2007) 1219-1228. Baratta, M. V., Christianson, J. P., Gomez, D. M., Zarza, C. M., Amat, J., Watkins, L. R., & Maier, S. F. Controllable versus uncontrollable stressors bidirectionally modulate conditioned but not innate fear. Neuroscience, 146 (2007) 1495-1503. Spataro, L.E., Downs, H., Wieseler, J., Watkins, L.R. & Oaklander, A.L., The persistent sciatic inflammatory neuropathy (SIN) rat model of neuropathic pain does not involve small-fiber axon damage, Journal of Neuropathic Pain & Symptom Palliation, 2 (2007) 41-47. Milligan, E.D., Soderquist, R.G., Malone, S., Mahoney, J.H., Hughes, T.S., Langer, S.J., Sloane, E.M., Maier, S.F., Leinwand, L.A., Watkins, L.R. & Mahoney, M.M., Neuropathic pain is controlled by i.t. interleukin-10 gene delivery using polymer-based nonviral vectors: an initial investigation, Neuron Glia Biology 2 (2007) 293-308. Der-Avakian, A., Bland, S.T., Rozeske, R.R., Tamblyn, J.T., Hutchinson, M.R., Watkins, L.R. & Maier, S.F., The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine and ethanol in rats, Psychopharmacology, 191 (2007) 909-917. Der-Avakian, A., Rozeske, R.R., Bland, S.T., Watkins, L.R. & Maier, S.F., The effects of a single session of inescapable tailshock on the subsequent locomotor response to brief footshock and cocaine administration in rats, Psychopharmacology, 101 (2007) 899-907. Holguin, A., Frank, M. G., Biedenkapp, J. C., Nelson, K., Lippert, D., Watkins,L.R., Rudy, J. W., & Maier, S. F. Characterization of the temporospatial effects of chronic bilateral intrahippocampal cannulae on interleukin-1 beta. Journal of Neuroscience Methods, 161 (2007) 185-376. Ledeober, A., Liu, T., Shumilla, J.A., Mahoney, J.H., Vijay, S., Gross, M.I., Vargas, J.A., Sultzbaugh, L., Claypool, M.D., Sanftner, L.M., Watkins, L.R., & Johnson, K.W., The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain, Neuron-Glia Biology Special issue on immune & glial regulation of pain, 2(2007) 279-291. Schoeniger-Skinner, D., Ledeboer, A., Frank, M.G., Milligan, E.D., Poole, S., Martin, D., Maier, S.F., & Watkins, L.R., Interleukin-6 mediates low threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120, Brain Behavior & Immunity, Special issue on immune & glial regulation of pain 21 (2007) 660-667. Bilbo, S.D., Newsum, N., Sprunger, D., Rudy, J., Watkins, L.R., & Maier, S.F., Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood, Brain Behavior & Immunity 21 (2007) 332-342. Ledeboer, A., Jekich, B., Sloane, E., Mahoney, J., Langer, S., Milligan, E.D., Maier, S.F., Johnson, K.W., Leinwand, L., Chavez, R., & Watkins, L.R., Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats, Brain Behavior & Immunity, 21 (2007) 686-698. Frank, M.G., Der-Avakian, A., Bland, S.T., Watkins, L.R. & Maier, S.F., Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression, Psychoneuroendocrinology 32 (2007) 376-384. Wieseler-Frank, J., Jekich, B.M., Maier, S.F. & Watkins, L.R., A novel immune-to CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to HIV-1 gp120, Brain, Behavior & Immunity, 21 (2007) 711-718. Ledeboer, A., Mahoney, J.H., Milligan, E.D., Martin, D., Maier, S.F., & Watkins, L.R., Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats, Journal of Pain, 7 (2006) 757-767. Frank, M.G., Baratta, M.B., Sprunger, D., Watkins, L.R., & Maier, S.F., Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS proinflammatory cytokine responses, Brain, Behavior & Immunity 21 (2007) 47-59. Bland, S.T., Schmid, M.J., Greenwood, B., Watkins, L.R., Maier, S.F., Behavioral control of the stressor modulates stress-induced changes in neurogenesis and fibroblast growth factor-2, Neuroreport 17 (2006) 593-7. Kleibeuker, W., Ledeboer, A., Eijkelkamp, N., Watkins, L.R., Maier, S.F. Zijlstra, J., Heijnen, C.J. & Kavelaars, A., A role for G protein-coupled receptor kinase 2 in mechanical allodynia, Eur. J. Neurosci., 25 (2007) 1696-1704.   Click here to go to What's New