Contact
Information

E-mail address: Heidi.Day@colorado.edu
Web address: http://psych.colorado.edu/~heididay
Office phone: 303-735-3815
Office Location: Muenzinger Bldg., Room E242
Fax: 303-492-2967
Mailing Address:
Department of Psychology
University of Colorado
Muenzinger D244
345 UCB
Boulder, CO 80309-0345

Research
Interests

My research focuses on how stress affects the brain and the body's subsequent physiological responses. I have three main areas of research:

1. How does psychological stress affect areas of the brain associated with emotional processing, especially within the central extended amygdala? What are the neuroanatomical pathways involved in this emotional processing?

2. How does voluntary exercise reduce physiological responses to a mild stressor, such as exposure to moderate noise or a novel environment? How does exercise affect the brain to cause these effects?

3. What are the differences between males and females in the response to stress? How are female responses to stress influenced by hormonal changes?

The research into stress responses is very strong on the Boulder campus, and I am fortunate to be able to collaborate with Drs. Serge Campeau, Moni Fleshner, Bob Spencer and Steve Maier.

Description of
Laboratory

My laboratory is combined with Dr. Serge Campeau's. We have an excellent modern research facility including a wet lab, image analysis suite, behavioral suite and newly renovated surgical suite. Available techniques include:

 

Behavioral
Various psychological stress paradigms, such as exposure to loud noise, predator odor, novelty and restraint; telemetry to measure heart rate, body temperature and gross motor activity; acoustic startle; defensive withdrawal.

Surgical
Stereotaxic techniques: cannula implantation, iontophoresis of anterograde and retrograde tracers, neurochemical lesions; catheter implantation (i.v. and i.p.); telemetry device implantation.

Immunohistochemistry
Single and Dual; Fluorescent

In situ hybridization
Single and Dual, and in combination with immunohistochemistry

Radioimmunoassay and ELISA
Measurement of hormones: corticosterone, ACTH, estradiol.

 

Current
Research
Opportunities

There are no openings in my lab at the present time.

 

Biographical
Information

2005 to present Assistant Research Professor, University of Colorado at Boulder, Psychology Department and Center for Neuroscience
1999 to 2005 Research Associate, University of Colorado at Boulder, Psychology Dept. (Dr. Serge Campeau)
1994 to 1999 Research Fellow, University of Michigan, Ann Arbor (Dr. Huda Akil)
1991 to 1994 Ph.D., University of Cambridge, U.K. (Dr. John Hughes)
1990 to 1991 M. Phil. University of Cambridge, U.K. (Dr. John Hughes)
1986 to 1990 B.Sc. (Hons.) University of Bath, U.K.

 

Select
Publications

  1. Day, H.E.W., Nebel, S., Sasse, S.K. and Campeau, S. (2005) Inhibition of the central extended amygdala by loud noise and restraint stress. Eur. J. Neurosci. 21, 441-454.
  2. Day, H.E.W., Masini, C.V. and Campeau S. (2004) Pattern of brain c-fos mRNA induced by a component of fox odor, 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), in rats, suggests both systemic and processive stress characteristics. Brain Res. 1025, 139-151
  3. Day, H.E.W., Greenwood, B.N., Hammack, S.E., Watkins, L.R., Fleshner, M., Maier, S.F. and Campeau, S. (2004) Differential expression of 5HT-1A, a1b adrenergic, CRH-R1 and CRH-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic and catecholaminergic cells of the rat dorsal raphe nucleus. J. Comp. Neurol. 474, 364-378
  4. Ginsberg, A.B., Campeau, S., Day, H.E.W., Spencer, R.L. (2003) Acute glucocorticoid pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis hormone secretion and expression of corticotropin-releasing hormone hnRNA but does not affect c-fos mRNA or fos protein expression in the paraventricular nucleus of the hypothalamus. J. Neuroendocrinol. 15, 1075-83.
  5. Greenwood, B.N., Foley, T.E., Day, H.E.W., Campisi, J., Hammock, S.H., Campeau, S., Maier, S.F., Fleshner, M. (2003) Freewheel running prevents learned helplessness/behavioral depression: Role of dorsal raphe serotonergic neurons. J. Neurosci. 23, 2889-2898.
  6. Greenwood, B.N., Kennedy, S., Smith, T.P., Campeau, S., Day, H.E.W. and Fleshner. M. (2003) Voluntary freewheel running selectively modulates catecholamine content in peripheral tissue and c-fos expression in the central sympathetic circuit following exposure to uncontrollable stress in rats. Neuroscience, 120, 269 – 281.
  7. Day, H.E.W., Vittoz, N.M., Oates, M.M., Badiani, A., Watson, S.J., Robinson, T.E. and Akil, H. (2002) A 6-hydroxydopamine lesion of the mesostriatal dopamine system decreases the expression of corticotropin releasing hormone and neurotensin mRNAs in the amygdala and bed nucleus of the stria terminalis. Brain Res. 945, 151-159
  8. Day, H.E.W., Badiani, A., Uslaner, J.M., Oates, M.M., Vittoz, N.M., Robinson, T.E., Watson, S.J. and Akil, H. (2001) Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdala. J. Neurosci., 21, 732 – 740
  9. Day, H.E.W., Campeau, S, Watson, S.J. and Akil, H. (1999) Expression of alpha-1b adrenoceptor mRNA in corticotropin-releasing hormone-containing cells of the rat hypothalamus and its regulation by corticosterone. J. Neurosci., 19, 10098-10106.
  10. Day, H.E.W., Curran, E.J., Watson S.J. and Akil, H. (1999) Distinct neurochemical populations in the rat central nucleus of the amygdala and bed nucleus of the stria terminalis: evidence for their selective activation by interleukin-1. J. Comp. Neurol., 413, 113-128.

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