Psyc 5112 Fall 2011: Genetics, Personality and Psychopathology

Professor:

Greg Carey
Mail: Dept. of Psychology, University of Colorado, Boulder CO 80309-0345 USA
Office: D261 Muenzinger
Phone: 303-492-1658
Fax:303-492-2967
Email: gregory.carey@colorado.edu
Home Page: http://http://psych.colorado.edu/~carey/HomePage.php

 

Overview:

This course will deal with the relationship between the genetics of personality and the genetics of psychopathology. The genetic epidemiology will be emphasized, not though any lack of interest in molecular genetics, but just because there are very few data in molecular genetics. The course will end with potential applications of the genetic epidemiology to molecular genetic studies.

 

Syllabus:

The syllabus is somewhat tentative.

Assessment and Psychometrics (Greg)
Reliability
Validity
Response Sets
Personality Theory and Measurement
Classic Trait Theory: Allport --> Catell --> Eysenck --> Big Five

Person x Situation

Empirical Scaling: MMPI & CPI
Biosocial & Evolutionary: Cloninger
Genetic Epidemiological Studies of Adult Personality
Basic Behavioral Genetics Methods (Greg)
Single Phenotypes:

Loehlin & Nichols (1976)

Eaves et al. (1993?)

MPQ results (Tellegen et al)

Stability
Relationships among Traits:

Heath

Stallings

Genetic Epidemiological Studies of Adult Psychopathology
Schizophrenia & schizotypy
Affective Disorders (broadly speaking)
Personality Disorders
Comorbidity
Multivariate Genetics of Personality and Psychopathology
Schizophrenia and Schizotypy
Eysenck, Anxiety, Depression
Personality Disorders as Extensions of Normal Personality
Molecular Genetics
GWAS

Interesting idea (McCrae)

Candidate Genes
Bootstrapping molecular Genetics

IRT and GWAS

 

Readings:

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Blonigen, D. M., Hicks, B. M., Krueger, R. F., Patrick, C. J., & Iacono, W. G. (2005). Psychopathic personality traits: Heritability and genetic overlap with internalizing and externalizing psychopathology. Psychological Medicine: A Journal of Research in Psychiatry and the Allied Sciences, 35(5), 637-648. doi:10.1017/S0033291704004180

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Cloninger, C. R. (1987). A systematic method for clinical description and classification of personality variants: A proposal. Archives of General Psychiatry, 44(6), 573-588.

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Goldberg, L. R., Johnson, J. A., Eber, H. W., Hogan, R., Ashton, M. C., Cloninger, C. R., & Gough, H. G. (2006). The international personality item pool and the future of public-domain personality measures. Journal of Research in Personality, 40(1), 84-96. doi:10.1016/j.jrp.2005.08.007

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Hicks, B. M., Blonigen, D. M., Kramer, M. D., Krueger, R. F., Patrick, C. J., Iacono, W. G., & McGue, M. (2007). Gender differences and developmental change in externalizing disorders from late adolescence to early adulthood: A longitudinal twin study. Journal of Abnormal Psychology, 116(3), 433-447. doi:10.1037/0021-843X.116.3.433

Hicks, B. M., Krueger, R. F., lacono, W. G., McGue, M., & Patrick, C. J. (2004). Family transmission and heritability of externalizing disorders: A twin-family study. Archives of General Psychiatry, 61(9), 922-928. doi:10.1001/archpsyc.61.9.922

Hicks, B. M., South, S. C., DiRago, A. C., Iacono, W. G., & McGue, M. (2009). Environmental adversity and increasing genetic risk for externalizing disorders. Archives of General Psychiatry, 66(6), 640-648. doi:10.1001/archgenpsychiatry.2008.554

Hopwood, C. J., Donnellan, M. B., Blonigen, D. M., Krueger, R. F., McGue, M., Iacono, W. G., & Burt, S. A. (2011). Genetic and environmental influences on personality trait stability and growth during the transition to adulthood: A three-wave longitudinal study. Journal of Personality and Social Psychology, 100(3), 545-556. doi:10.1037/a0022409

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Jang, K. L., Livesley, W. J., Ando, J., Yamagata, S., Suzuki, A., Angleitner, A., . . . Spinath, F. (2006). Behavioral genetics of the higher-order factors of the big five. Personality and Individual Differences, 41(2), 261-272. doi:10.1016/j.paid.2005.11.033

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Kendler, K. S., & Myers, J. (2010). The genetic and environmental relationship between major depression and the five-factor model of personality. Psychological Medicine: A Journal of Research in Psychiatry and the Allied Sciences, 40(5), 801-806. doi:10.1017/S003329170999114

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Addendum: Class Motto

Quantum materiae materietur marmota monax si marmota monax materiam possit materiari?