Professor:
Greg Carey
Mail: Dept. of Psychology, University of Colorado, Boulder CO 80309-0345 USA
Office: D261 Muenzinger
Phone: 303-492-1658
Fax:303-492-2967
Email: gregory.carey@colorado.edu
Home Page: http://http://psych.colorado.edu/~carey/HomePage.php
Overview:
This course will deal with the relationship between the genetics of personality and the genetics of psychopathology. The genetic epidemiology will be emphasized, not though any lack of interest in molecular genetics, but just because there are very few data in molecular genetics. The course will end with potential applications of the genetic epidemiology to molecular genetic studies.
Syllabus:
The syllabus is somewhat tentative.
Assessment and Psychometrics (Greg)
Reliability
Validity
Response Sets
Personality Theory and Measurement
Classic Trait Theory: Allport --> Catell --> Eysenck --> Big Five
Person x Situation
Empirical Scaling: MMPI & CPI
Biosocial & Evolutionary: Cloninger
Genetic Epidemiological Studies of Adult Personality
Basic Behavioral Genetics Methods (Greg)
Single Phenotypes:
Loehlin & Nichols (1976)
Eaves et al. (1993?)
MPQ results (Tellegen et al)
Stability
Relationships among Traits:
Heath
Stallings
Genetic Epidemiological Studies of Adult Psychopathology
Schizophrenia & schizotypy
Affective Disorders (broadly speaking)
Personality Disorders
Comorbidity
Multivariate Genetics of Personality and Psychopathology
Schizophrenia and Schizotypy
Eysenck, Anxiety, Depression
Personality Disorders as Extensions of Normal Personality
Molecular Genetics
GWAS
Interesting idea (McCrae)
Candidate Genes
Bootstrapping molecular Genetics
IRT and GWAS
Readings:
Adorno, T. W., Frenkel-Brunswick, E., Levinson, D. J., & Sanford, R. N. (1950). The authoritarian personality. New York: Harper.
Allport, G. W., & Odbert, H. S. (1936). Traitnames. A psycho-lexical study. Psychological Monographs, 47, 211, 171-171.
Beer, J. M., Arnold, R. D., & Loehlin, J. C. (1998). Genetic and environmental influences on MMPI factor scales: Joint model fitting to twin and adoption data. J Pers Soc Psychol, 74(398184022), 818-827.
Blonigen, D. M., Hicks, B. M., Krueger, R. F., Patrick, C. J., & Iacono, W. G. (2005). Psychopathic personality traits: Heritability and genetic overlap with internalizing and externalizing psychopathology. Psychological Medicine: A Journal of Research in Psychiatry and the Allied Sciences, 35(5), 637-648. doi:10.1017/S0033291704004180
Borkenau, P., Riemann, R., Angleitner, A., & Spinath, F. M. (2001). Genetic and environmental influences on observed personality: Evidence from the German observational study of adult twins. Journal of Personality and Social Psychology, 80(4), 655-668. doi:10.1037/0022-3514.80.4.655
Bouchard, T. J. J., McGue, M., Hur, Y., & Horn, J. M. (1998). A genetic and environmental analysis of the California Psychological Inventory using adult twins reared apart and together. European Journal of Personality, 12(5), 307-320. doi:10.1002/(SICI)1099-0984(1998090)12:5<307::AID-PER336>3.3.CO;2-B
Buss, A. H., & Plomin, R. (1975). A temperament theory of personality development. New York: Wiley.
Buss, D. M. (2009). An evolutionary formulation of person-situation interactions. Journal of Research in Personality, 43(2), 241-242. doi:10.1016/j.jrp.2008.12.019
Buss, D. M. (2009). How can evolutionary psychology successfully explain personality and individual differences? Perspectives on Psychological Science.Special Issue: Next Big Questions in Psychology, 4(4), 359-366. doi:10.1111/j.1745-6924.2009.01138.x
Butcher, J. N. (2009). Oxford handbook of personality assessment. New York, NY, US: Oxford University Press.
Cale, E. M. (2006). A quantitative review of the relations between the "big 3" higher order personality dimensions and antisocial behavior. Journal of Research in Personality, 40(3), 250-284. doi:10.1016/j.jrp.2005.01.001
Carey, G., & DiLalla, D. L. (1994). Personality and psychopathology: Genetic perspectives. Journal of Abnormal Psychology.Special Issue: Personality and Psychopathology, 103(1), 32-43. doi:10.1037/0021-843X.103.1.32
Cattell, R. B. (1947). Confirmation and clarification of primary personality factors. Psychometrika, 12, 197-220. doi:10.1007/BF02289253
Cattell, R. B. (1956). A shortened "basic english" version (form C) of the 16 PF questionnaire. The Journal of Social Psychology, 44, 257-278.
Cipriani, D. C. (1996). Stability and change in personality across the life span: Behavioral-genetic versus evolutionary approaches. Genetic, Social, and General Psychology Monographs, 122(1), 55-74.
Cloninger, C. R. (1987). Neurogenetic adaptive mechanisms in alcoholism. Science, 236(4800), 410-416. doi:10.1126/science.2882604
Cloninger, C. R. (1987). A systematic method for clinical description and classification of personality variants: A proposal. Archives of General Psychiatry, 44(6), 573-588.
Cloninger, C. R., Svrakic, D. M., & Przybeck, T. R. (1993). A psychobiological model of temperament and character. Archives of General Psychiatry, 50(12), 975-990.
Cronbach, L. J., & Meehl, P. M. (1955). Construct validity in psychological tests. Psychological Bulletin, 52, 281-302.
Cronbach, L. J. (1951). Coefficient alpha and the internal structure of tests. Psychometrika, 16, 297-334. doi:10.1007/BF02310555
De Fruyt, F., Bartels, M., Van Leeuwen, K. G., De Clercq, B., Decuyper, M., & Mervielde, I. (2006). Five types of personality continuity in childhood and adolescence. Journal of Personality and Social Psychology, 91(3), 538-552. doi:10.1037/0022-3514.91.3.538
DiLalla, D. L., & Carey, G. (2004). In DiLalla L. F. (Ed.), Genetic correlations as "z" variables: Evaluating personality?psychopathology associations. Washington, DC, US: American Psychological Association. doi:10.1037/10684-005
Eaves, L. J., Eysenck, H. J., & Martin, N. G. (1989). Genes, culture and personality: An empirical approach. San Diego CA: Academic Press.
Eaves, L., & Eysenck, H. (1975). The nature of extraversion: A genetical analysis. Journal of Personality and Social Psychology, 32(1), 102-112. doi:10.1037/h0076862
Eysenck, H. J. (1990). Genetic and environmental contributions to individual differences: The three major dimensions of personality. Journal of Personality.Special Issue: Biological Foundations of Personality: Evolution, Behavioral Genetics, and Psychophysiology, 58(1), 245-261. doi:10.1111/j.1467-6494.1990.tb00915.x
Ferguson, C. J. (2010). Genetic contributions to antisocial personality and behavior: A meta-analytic review from an evolutionary perspective. The Journal of Social Psychology, 150(2), 160-180. doi:10.1080/00224540903366503
Figueredo, A. J., Gladden, P., Vásquez, G., Wolf, P. S. A., & Jones, D. N. (2009). In Corr P. J., Matthews G. (Eds.), Evolutionary theories of personality. New York, NY, US: Cambridge University Press.
Forsman, M., Lichtenstein, P., Andershed, H., & Larsson, H. (2010). A longitudinal twin study of the direction of effects between psychopathic personality and antisocial behaviour. Journal of Child Psychology and Psychiatry, 51(1), 39-47. doi:10.1111/j.1469-7610.2009.02141.x
Gagne, J. R., & Goldsmith, H. H. (2011). A longitudinal analysis of anger and inhibitory control in twins from 12 to 36 months of age. Developmental Science, 14(1), 112-124. doi:10.1111/j.1467-7687.2010.00969.x
Gangestad, S. W. (2010). Evolutionary biology looks at behavior genetics. Personality and Individual Differences, 49(4), 289-295. doi:10.1016/j.paid.2010.03.005
Gangestad, S., & Snyder, M. (1985). "To carve nature at its joints": On the existence of discrete classes in personality. Psychological Review, 92(3), 317-349. doi:10.1037/0033-295X.92.3.317
Gillespie, N. A., Cloninger, C. R., Heath, A. C., & Martin, N. G. (2003). The genetic and environmental relationship between cloninger's dimensions of temperament and character. Personality and Individual Differences, 35(8), 1931-1946. doi:10.1016/S0191-8869(03)00042-4
Goldberg, L. R. (1993). The structure of phenotypic personality traits. American Psychologist, 48(1), 26-34. doi:10.1037/0003-066X.48.1.26
Goldberg, L. R., Johnson, J. A., Eber, H. W., Hogan, R., Ashton, M. C., Cloninger, C. R., & Gough, H. G. (2006). The international personality item pool and the future of public-domain personality measures. Journal of Research in Personality, 40(1), 84-96. doi:10.1016/j.jrp.2005.08.007
Goldsmith, H. H., Lemery, K. S., Buss, K. A., & Campos, J. J. (1999). Genetic analyses of focal aspects of infant temperament. Developmental Psychology, 35, 972-985. DOI: 10.1037/0012-1649.35.4.972
Heath, A. C., Cloninger, C. R., & Martin, N. G. (1994). Testing a model for the genetic structure of personality: A comparison of the personality systems of Cloninger and Eysenck. Journal of Personality and Social Psychology, 66(4), 762-775. doi:10.1037/0022-3514.66.4.762
Heath, A. C., Madden, P. A., Cloninger, C. R., & Martin, N. G. (1999). In Cloninger C. R. (Ed.), Genetic and environmental structure of personality. Washington, DC, US: American Psychiatric Association.
Heath, A. C., & Martin, N. G. (1990). Psychoticism as a dimension of personality: A multivariate genetic test of eysenck and eysenck's psychoticism construct. Journal of Personality and Social Psychology, 58(1), 111-121. doi:10.1037/0022-3514.58.1.111
Heath, A.C., Neale, M.C, Kessler, R.C., Eaves, L.J., , & Kendler, K.S.. (1992). Evidence for genetic influences on personality from self-reports and informant ratings. Journal of Personality and Social Psychology, 63, 85-96.
Hicks, B. M., Blonigen, D. M., Kramer, M. D., Krueger, R. F., Patrick, C. J., Iacono, W. G., & McGue, M. (2007). Gender differences and developmental change in externalizing disorders from late adolescence to early adulthood: A longitudinal twin study. Journal of Abnormal Psychology, 116(3), 433-447. doi:10.1037/0021-843X.116.3.433
Hicks, B. M., Krueger, R. F., lacono, W. G., McGue, M., & Patrick, C. J. (2004). Family transmission and heritability of externalizing disorders: A twin-family study. Archives of General Psychiatry, 61(9), 922-928. doi:10.1001/archpsyc.61.9.922
Hicks, B. M., South, S. C., DiRago, A. C., Iacono, W. G., & McGue, M. (2009). Environmental adversity and increasing genetic risk for externalizing disorders. Archives of General Psychiatry, 66(6), 640-648. doi:10.1001/archgenpsychiatry.2008.554
Hopwood, C. J., Donnellan, M. B., Blonigen, D. M., Krueger, R. F., McGue, M., Iacono, W. G., & Burt, S. A. (2011). Genetic and environmental influences on personality trait stability and growth during the transition to adulthood: A three-wave longitudinal study. Journal of Personality and Social Psychology, 100(3), 545-556. doi:10.1037/a0022409
Jackson, D. N., & Messick, S. (1958). Content and style in personality assessment. Psychological Bulletin, 55(4), 243-252. doi:10.1037/h0045996
Jang, K. L. (., Wolf, H. (., & Larstone, R. (. (2006). What is the role of personality in psychopathology?: A view from behavior genetics. In R. F. Krueger, & J. L. Tackett (Eds.), Personality and psychopathology. (pp. 153-173). New York, NY, US: Guilford Press.
Jang, K. L., Livesley, W. J., Ando, J., Yamagata, S., Suzuki, A., Angleitner, A., . . . Spinath, F. (2006). Behavioral genetics of the higher-order factors of the big five. Personality and Individual Differences, 41(2), 261-272. doi:10.1016/j.paid.2005.11.033
Johnson, W., McGue, M., & Krueger, R. F. (2005). Personality stability in late adulthood: A behavioral genetic analysis. Journal of Personality, 73(2), 523-551. doi:10.1111/j.1467-6494.2005.00319.x
Kandler, C., Bleidorn, W., Riemann, R., Spinath, F. M., Thiel, W., & Angleitner, A. (2010). Sources of cumulative continuity in personality: A longitudinal multiple-rater twin study. Journal of Personality and Social Psychology, 98(6), 995-1008. doi:10.1037/a0019558
Kendler, K. S., & Myers, J. (2010). The genetic and environmental relationship between major depression and the five-factor model of personality. Psychological Medicine: A Journal of Research in Psychiatry and the Allied Sciences, 40(5), 801-806. doi:10.1017/S003329170999114
Kendler, K. S., Gatz, M., Gardner, C. O., & Pederse, N. L. (2006). Personality and major depression. Archives of General Psychiatry, 63(10), 1113-1120. doi:10.1001/archpsyc.63.10.1113
Krueger, R. F., Eaton, N. R., Clark, L. A., Watson, D., Markon, K. E., Derringer, J., . . . John Livesley, W. (2011). Deriving an empirical structure of personality pathology for DSM-5. Journal of Personality Disorders.Special Issue: Proposals for DSM-5, 25(2), 170-191. doi:10.1521/pedi.2011.25.2.170
Krueger, R. F., Hicks, B. M., Patrick, C. J., Carlson, S. R., Iacono, W. G., & McGue, M. (2002). Etiologic connections among substance dependence, antisocial behavior and personality: Modeling the externalizing spectrum. Journal of Abnormal Psychology, 111(3), 411-424. doi:10.1037/0021-843X.111.3.411
Krueger, R. F., & Markon, K. E. (2006). Understanding psychopathology: Melding behavior genetics, personality, and quantitative psychology to develop an empirically based model. Current Directions in Psychological Science, 15(3), 113-117. doi:10.1111/j.0963-7214.2006.00418.x
Krueger, R. F., Markon, K. E., Patrick, C. J., & Iacono, W. G. (2005). Externalizing psychopathology in adulthood: A dimensional-spectrum conceptualization and its implications for DSM-V. Journal of Abnormal Psychology.Special Issue: Toward a Dimensionally Based Taxonomy of Psychopathology, 114(4), 537-550. doi:10.1037/0021-843X.114.4.537
Krueger, R. F., Markon, K. E., & Bouchard, T. J. (2003). The extended genotype: The heritability of personality accounts for the heritability of recalled family environments in twins reared apart. Journal of Personality, 71(5), 809-833. doi:10.1111/1467-6494.7105005
Loehlin, J. C., & Nichols, R. C. (1976). Heredity, environment, and personality. Austin TX: University of Texas Press.
Loehlin, J. C., McCrae, R. R., Costa, P. T. J., & John, O. P. (1998). Heritabilities of common and measure-specific components of the big five personality factors. Journal of Research in Personality, 32(4), 431-453. doi:10.1006/jrpe.1998.2225
Lykken, D. T., Bouchard, T. J., McGue, M., & Tellegen, A. (1993). Heritability of interests: A twin study. Journal of Applied Psychology, 78(4), 649-661. doi:10.1037/0021-9010.78.4.649
Lykken, D. T., McGue, M., Bouchard, T. J., & Tellegen, A. (1990). Does contact lead to similarity or similarity to contact? Behavior Genetics, 20(5), 547-561. doi:10.1007/BF01065871
Lykken, D., & Tellegen, A. (1996). Happiness is a stochastic phenomenon. Psychological Science, 7(3), 186-189. doi:10.1111/j.1467-9280.1996.tb00355.x
Markon, K. E., Krueger, R. F., Bouchard, T. J. J., & Gottesman, I. I. (2002). Normal and abnormal personality traits: Evidence for genetic and environmental relationships in the Minnesota study of twins reared apart. Journal of Personality, 70(5), 661-693. doi:10.1111/1467-6494.05020
Markon, K. E., Krueger, R. F., & Watson, D. (2005). Delineating the structure of normal and abnormal personality: An integrative hierarchical approach. Journal of Personality and Social Psychology, 88(1), 139-157. doi:10.1037/0022-3514.88.1.139
McCrae, R. R., & Costa, P. T. J. (1999). A five-factor theory of personality. In L. A. Pervin, & O. P. John (Eds.), Handbook of personality research, 2nd ed. (pp. 139-153). New York: Guilford Press.
McCrae, R. R., Jang, K. L., Livesley, W. J., Riemann, R., & Angleitner, A. (2001). Sources of structure: Genetic, environmental, and artifactual influences on the covariation of personality traits. Journal of Personality, 69(4), 511-535. doi:10.1111/1467-6494.694154
McCrae, R. R., & John, O. P. (1992). An introduction to the five-factor model and its applications. Journal of Personality.Special Issue: The Five-Factor Model: Issues and Applications, 60(2), 175-215. doi:10.1111/j.1467-6494.1992.tb00970.x
McCrae, R. R., Scally, M., Terracciano, A., Abecasis, G. R., & Costa, P. T. (2010). An alternative to the search for single polymorphisms: Toward molecular personality scales for the five-factor model. Journal of Personality and Social Psychology, 99(6), 1014-1024. doi:10.1037/a0020964
McCrae, R. R., Yamagata, S., Jang, K. L., Riemann, R., Ando, J., Ono, Y., . . . Spinath, F. M. (2008). Substance and artifact in the higher-order factors of the big five. Journal of Personality and Social Psychology, 95(2), 442-455. doi:10.1037/0022-3514.95.2.442
McGue, M., Bacon, S., & Lykken, D. T. (1993). Personality stability and change in early adulthood: A behavioral genetic analysis. Developmental Psychology, 29(1), 96-109. doi:10.1037/0012-1649.29.1.96
Messick, S., & Jackson, D. N. (1961). Acquiescence and the factorial interpretation of the MMPI. Psychological Bulletin, 58(4), 299-304. doi:10.1037/h0043979
Mischel, W. (1973). Toward a cognitive social learning reconceptualization of personality. Psychological Review, 80(4), 252-283. doi:10.1037/h0035002
Mischel, W., & Shoda, Y. (1995). A cognitive-affective system theory of personality: Reconceptualizing situations, dispositions, dynamics, and invariance in personality structure. Psychological Review, 102(2), 246-268. doi:10.1037/0033-295X.102.2.246
Moore, M., Schermer, J. A., Paunonen, S. V., & Vernon, P. A. (2010). Genetic and environmental influences on verbal and nonverbal measures of the big five. Personality and Individual Differences, 48(8), 884-888. doi:10.1016/j.paid.2010.02.015
Mullineaux, P. Y., Deater-Deckard, K., Petrill, S. A., Thompson, L. A., & DeThorne, L. S. (2009). Temperament in middle childhood: A behavioral genetic analysis of fathers’ and mothers’ reports. Journal of Research in Personality, 43(5), 737-746. doi:10.1016/j.jrp.2009.04.008
Neale, M. C., & Stevenson, J. (1989). Rater bias in the EASI temperament scales: A twin study. Journal of Personality & Social Psychology, 56(3Journal Article Mar 1989 English Empirical Study), 446-455.
Pakkala, I., Read, S., Kaprio, J., Koskenvuo, M., Kauppinen, M., & Rantanen, T. (2010). Genetic contribution to the relationship between personality and depressive symptoms among older women. Psychological Medicine: A Journal of Research in Psychiatry and the Allied Sciences, 40(8), 1357-1366. doi:10.1017/S0033291709991401
Patrick, C. J., Fowles, D. C., & Krueger, R. F. (2009). Triarchic conceptualization of psychopathy: Developmental origins of disinhibition, boldness, and meanness. Development and Psychopathology, 21(3), 913-938. doi:10.1017/S0954579409000492
Pedersen, N. L., & Reynolds, C. A. (1998). Stability and change in adult personality: Genetic and environmental components. European Journal of Personality, 12(5), 365-386. doi:10.1002/(SICI)1099-0984(1998090)12:5<365::AID-PER335>3.0.CO;2-N
Phillips, K., & Matheny, A. P.,Jr. (1997). Evidence for genetic influence on both cross-situation and situation-specific components of behavior. Journal of Personality & Social Psychology, 73, 129-138.
Plomin, R., Emde, R. N., Braungart, J. M., Campos, J., Corley, R., Fulker, D. W., . . . et al. (1993). Genetic change and continuity from fourteen to twenty months: The MacArthur longitudinal twin study. Child Dev, 64(594038234), 1354-1376.
Read, S., Vogler, G. P., Pedersen, N. L., & Johansson, B. (2006). Stability and change in genetic and environmental components of personality in old age. Personality and Individual Differences, 40(8), 1637-1647. doi:10.1016/j.paid.2006.01.004
Riemann, R., Angleitner, A., & Strelau, J. (1997). Genetic and environmental influences on personality: A study of twins reared together using the self- and peer-report NEO- FFI scales. Journal of Personality, 65, 449-475.
Rowe, D. C., & Plomin, R. (1977). Temperament in early childhood. Journal of Personality Assessment, 41, 150-156.
Samuel, D. B., Simms, L. J., Clark, L. A., Livesley, W. J., & Widiger, T. A. (2010). An item response theory integration of normal and abnormal personality scales. Personality Disorders: Theory, Research, and Treatment, 1(1), 5-21. doi:10.1037/a0018136
Schermer, J. A., Johnson, A. M., Vernon, P. A., & Jang, K. L. (2011). The relationship between personality and self-report abilities: A behavior-genetic analysis. Journal of Individual Differences, 32(1), 47-53. doi:10.1027/1614-0001/a000035
Schmitz, S., Saudino, K. J., Plomin, R., Fulker, D. W., & DeFries, J. C. (1996). Genetic and environmental influences on temperament in middle childhood: Analyses of teacher and tester ratings. Child Dev, 67(296209268), 409-422.
Stallings, M. C., Hewitt, J. K., Cloninger, C. R., Heath, A. C., & Eaves, L. J. (1996). Genetic and environmental structure of the tridimensional personality questionnaire: Three or four temperament dimensions? Journal of Personality and Social Psychology, 70(1), 127-140. doi:10.1037/0022-3514.70.1.127
Tellegen, A., Lykken, D. T., Bouchard, T. J.,Jr, Wilcox, K. J., Segal, N. L., & Rich,S. (1988). Personality similarity in twins reared apart and together. J Pers Soc Psychol, 54(6), 1031-1039.
Thurstone, L. L. (1934). The vectors of mind. Psychological Review, 41(1), 1-32. doi:10.1037/h0075959
Thurstone, L. L. (1951). The dimensions of temperament. Psychometrika, 16, 11-20. doi:10.1007/BF02313423
Viken, R. J., Rose, R. J., Kaprio, J., & Koskenvuo, M. (1994). A developmental genetic analysis of adult personality: Extraversion and neuroticism from 18 to 59 years of age. Journal of Personality & Social Psychology, 66(4Journal Article Apr 1994 English Empirical Study; Followup Study), 722-730.
Waller, N. G., Lykken, D. T., & Tellegen, A. (1995). Occupational interests, leisure time interests, and personality: Three domains or one? findings from the Minnesota twin registry. In D. J. Lubinski, R. V. Dawis, D. J. Lubinski & R. V. Dawis (Eds.), Assessing individual differences in human behavior: New concepts, methods, and findings. (pp. 233-259). Palo Alto, CA, US: Davies-Black Publishing.
Weiss, A. (., & King, J. E. (. (2006). Searching for genetic and environmental contributions to personality and happiness in chimpanzees (pan troglodytes). In T. Canli (Ed.), Biology of personality and individual differences. (pp. 407-426). New York, NY, US: Guilford Press.
Weiss, A., Adams, M. J., Widdig, A., & Gerald, M. S. (2011). Rhesus macaques (macaca mulatta) as living fossils of hominoid personality and subjective well-being. Journal of Comparative Psychology, 125(1), 72-83. doi:10.1037/a0021187
Yamagata, S., Suzuki, A., Ando, J., Ono, Y., Kijima, N., Yoshimura, K., . . . Jang, K. L. (2006). Is the genetic structure of human personality universal? A cross-cultural twin study from north america, europe, and asia. Journal of Personality and Social Psychology, 90(6), 987-998. doi:10.1037/0022-3514.90.6.987
Addendum: Class Motto
Quantum materiae materietur marmota monax si marmota monax materiam possit materiari?