Ruth M. Barrientos, Ph.D.

 

Publications

Peer-Reviewed Papers


  1. 1.Spencer, S.J., Korosi, A., Layé, S., Shukitt-Hale, B., Barrientos, R.M. Food for thought: How nutrition impacts cognition and emotion. Science of Food, 2017, in press.

  2. 2.Spencer, S.J., D’Angelo, H.M., Soch, A., Watkins, L.R., Maier, S.F., Barrientos, R.M. High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory. Neurobiology of Aging, 2017, 58: 88-101.

  3. 3.Baartman, T.L., Swanepoel, T., Barrientos, R.M., Laburn, H.P., Mitchell, D., Harden, L.M. Divergent effects of brain interleukin-1ß in mediating fever, lethargy, anorexia and conditioned fear memory. Behavioural Brain Research, 2017 324: 155-163.

  4. 4.Barrientos, R.M., Kitt, M.M., D’Angelo, H.M., Watkins, L.R., Rudy, J.W., Maier, S.F. Stable, long-term spatial memory in young and aged rats achieved with a 1 day Morris water maze protocol. Learning & Memory, 2016, 23: 699-702.

  5. 5.Sobesky, J.L., D’Angelo, H.M., Weber, M.D., Anderson, N.D., Frank, M.G., Watkins, L.R., Maier, S.F., Barrientos, R.M. Glucocorticoids mediate short-term high-fat diet induction of neuroinflammatory priming, the NLRP3 inflammasome, and the danger signal HMGB1. eNeuro, 2016, 3(4): 1-17.

  6. 6.Fonken, L.K., Kitt, M.M., Gaudet, A.D., Barrientos, R.M., Watkins, L.R., Maier, S.F. Diminished circadian rhythms in microglia may contribute to age-related neuroinflammatory sensitization. Neurobiology of Aging, 2016, 47: 102-112.

  7. 7.Fonken, L.K., Frank, M.G., Kitt, M.M., D’Angelo, H.M., Norden, D.M., Weber, M.D. Barrientos, R.M., Godbout, J.P., Watkins, L.R., Maier, S.F. The alarmin HMGB1 mediates age-induced priming of the neuroinflammatory and sickness response. Journal of Neuroscience, 2016, 36(30): 7945:7956.

  8. 8.Barrientos, R.M., Kitt, M.M., Watkins, L.R., Maier, S.F. Neuroinflammation in the normal aging hippocampus. Neuroscience, 2015, 309, 84-99. (Invited Review)

  9. 9.Barrientos, R.M., Thompson, V.M., Kitt, M.M., Amat, J., Hale, M.W., Frank, M.G., Crysdale, N.Y.,  Stamper, C.E., Hennessey, P.A., Watkins, L.R., Spencer, R.L., Lowry, C.A., Maier, S.F. Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia. Neurobiology of Aging, 2015, 36, 1483-1495.

  10. 10.Fonken, L.K., Frank, M.G., Kitt, M.M., Barrientos, R.M., Watkins, L.R., Maier, S.F. Microglia inflammatory responses are controlled by an intrinsic circadian clock. Brain, Behavior, & Immunity, 2015, 45, 171-179.

  11. 11.Stolyarova, A., Rodriguez, D., Thompson, A., Barrientos, R.M., Izquierdo, A. Reduction in frontocortical cytokine levels predict long-lasting alterations in reward valuation after methamphetamine. Neuropsychopharmacology, 2015, 40, 1234-1242.

  12. 12.Barrientos, R.M., Thompson, V.M., Arnold, T.H., Frank, M.G., Watkins, L.R., Maier, S.F., The role of hepatic & splenic macrophages in E. coli-induced memory impairments in aged rats. Brain, Behavior, & Immunity, 2015, 43: 60-67.

  13. 13.Sobesky, J.L., Barrientos, R.M., De May, H.S., Thompson, B.M., Weber, M.D., Watkins, L.R., Maier, S.F. High-fat diet consumption disrupts memory and primes hippocampal IL-1beta, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism. Brain, Behavior, & Immunity, 2014, 42: 22-32.

  14. 14.Barrientos, R.M. Book Review: Immunosenescence: Psychosocial and Behavioral Determinants. Bosch, J.A., Phillips, A.C., Lord, J.M. (Eds.), Springer, 2013.  Brain, Behavior, & Immunity, 2014, 37: 267-268.

  15. 15.Barrientos, R.M., Hein, A.M., Frank, M.G., Watkins, L.R., Maier, S.F. Intracisternal interleukin-1 receptor antagonist (IL-1RA) prevents post-operative cognitive decline and neuroinflammatory response in aged rats. Journal of Neuroscience, 2012, 32(42): 14641-14648.

  16. 16.Barrientos, R.M. The role of microglia in neurogenesis: Exercise and aging as co-factors. Future Neurology, 2012, 7(6): 671-674. (Invited Priority Paper Evaluation) *not peer-reviewed

  17. 17.Frank, M.G., Barrientos, R.M., Thompson, B.M., Weber, M.D., Watkins, L.R., Maier, S.F. IL-1RA injected ICM confers extended prophylaxis against LPS-induced neuroinflammatory and sickness responses. Journal of Neuroimmunology, 2012, 252(1-2): 33-39.

  18. 18.Barrientos, R.M., Frank, M.G., Watkins, L.R., Maier, S.F. Aging-related changes in neuroimmune-endocrine function: Implications for hippocampal-dependent cognition. Hormones & Behavior, 2012, 62(3): 219-227. (Invited Review)

  19. 19.Chapman, T.R., Barrientos, R.M., Ahrendsen, J.T., Hoover, J.M., Maier, S.F., Patterson, S.L. Aging and infection reduce expression of specific BDNF mRNAs in hippocampus. Neurobiology of Aging, 2012, 33(4): 832.e1-14.

  20. 20.Barrientos, R.M., Frank, M.G., Crysdale, N.Y., Chapman, T. R., Ahrendsen, J., Campeau, S, Day, H.E.W., Watkins, L.R., Patterson, S.L., Maier, S.F. Little exercise, big effects: Reversing aging and infection-induced memory deficts, and underlying processes. Journal of Neuroscience, 2011, 31(32): 11578-11586.

  21. 21.Hains, L.E., Loram, L.C., Taylor, F., Strand, K. Wieseler, J.L., Barrientos, R.M., Young, J.J., Frank, M.G., Sobesky, J., Martin, T.J., Eisenach, J.C., Maier, S.F., Johnson, J.D., Fleshner, M.R., & Watkins, L.R. Immune priming with prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. Journal of Neuroimmunology, 2011, 239(1-2): 53-60.

  22. 22.Barrientos, R.M. Voluntary exercise as an anti-neuroinflammatory therapeutic. Brain, Behavior & Immunity, 2011, 25(6): 1061-1062.

  23. 23.Cortese, G.P., Barrientos, R.M., Maier, S.F., Patterson, S.L. Aging and a peripheral immune challenge interact to reduce mBDNF and activation of TrkB, PLC gamma, and ERK in hippocampal synaptoneurosomes. Journal of Neuroscience, 2011. 31(11): 4274-4279.

  24. 24.Frank, M.G., Barrientos, R.M., Watkins, L.R., Maier, S.F. Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo. Journal of Neuroimmunology, 2010, 226(1-2): 181-184.

  25. 25.Chapman, T.R., Barrientos, R.M., Ahrendsen, J.T., Maier, S.F., Patterson, S.L., Synaptic correlates of increased cognitive vulnerability with aging: Peripheral immune challenge and  aging interact to disrupt theta-burst L-LTP in hippocampal area CA1. Journal of Neuroscience, 2010, 30(22): 7598-7603.

  26. 26.Frank, M.G., Barrientos, R.M., Hein A.M., Biedenkapp, J.C., Watkins, L.R., Maier, S.F. IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344 x BN F1 rats. Brain, Behavior & Immunity, 2010, 24(2): 254-262.

  27. 27.Barrientos, R.M., Frank, M.G., Watkins, L.R., Maier, S.F. Memory impairments in healthy aging: Role of aging-induced microglial sensitization. Special Issue on Neuroimmunomodulation and Aging, Aging and Disease, 2010, 1(3): 212-231. (Invited Review) pdf

  28. 28.Bilbo, S.D., Wieseler, J., Barrientos, R.M., Tsang, V., Watkins, L.R., & Maier, S.F.. Neonatal bacterial infection alters fever to live and simulated infections in adulthood.  Psychoneuroendocrinology, 2010, 35(3): 369-381.

  29. 29.Barrientos, R.M., Watkins, L.R., Rudy, J.W., Maier, S.F. Characterization of the sickness response in young and aging rats following E. coli infection. Brain, Behavior, & Immunity, 2009, 23(4): 450-454.

  30. 30.Barrientos, R.M., Frank, M.G., Hein, A.M., Higgins, E.A., Watkins, L.R., Rudy, J.W., Maier, S.F. Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain, Behavior, & Immunity. 2009, 23(1):46-54.

  31. 31.Bilbo SD, Barrientos RM, Eads AS, Northcutt A, Watkins LR, Rudy JW, Maier SF. Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood. Brain, Behavior, & Immunity. 2008, 22(4): 451-5.

  32. 32.Hein, A.M., Stutzman, D.L., Bland, S.T., Barrientos, R.M., Watkins, L.R., Rudy, J.W., Maier, S.F.. Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus. Neuroscience. 2007, 150(4):754-63.

  33. 33.Bland, S.T., Tamblyn, J.P., Barrientos, R. M., Greenwood, B.N., Watkins, L.R., Campeau, S., Day, H.E., Maier, S.F.  Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or controllable stress.  Neuroscience, 2007, 144(4): 1219-1228.

  34. 34.Barrientos, R. M., Higgins, E. A., Biedenkapp, J. C., Sprunger, D. B., Wright-Hardesty, K. J., Watkins, L. R., Rudy, J. W., Maier, S. F. Peripheral infection and aging interact to impair hippocampal memory consolidation.  Neurobiology of Aging, 2006, 27(5): 723-732.

  35. 35.Frank, M.G., Barrientos, R.M., Biedenkapp, J.C., Rudy, J. W., Watkins, L.R., Maier, S.F.  mRNA up-regulation of MHCII and pivotal pro-inflammatory genes in normal brain aging.  Neurobiology of Aging, 2006, 27(5): 717-722.

  36. 36.Spataro, L.E., Sloane, E.M., Milligan, E.D., Wieseler-Frank, J., Schoeniger, D., Jekich, B.M., Barrientos, R.M., Maier, S.F., & Watkins, L.R.  Spinal gap junctions: Potential involvement in pain facilitation.  Journal of Pain, 2004, 5(7): 392-405.

  37. 37.Barrientos, R.M., Sprunger, D.B., Campeau, S., Watkins, L.R., Rudy, J.W.,  Maier, S.F.  BDNF mRNA expression in hippocampus following contextual learning is blocked by intrahippocampal IL-1 beta administration.  Journal of Neuroimmunology, 2004, 155(1-2): 119-126.

  38. 38.Chacur, M., Milligan, E.D., Sloane, E.M., Wieseler-Frank, J., Barrientos, R.M., Martin, D., Poole, S., Lomonte, B., Gutiérrez, J.M., Maier, S.F., Cury, Y., & Watkins, L.R.  Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: Involvement of spinal cord glia, proinflammatory cytokines and nitric oxide. Pain, 2004, 108(1): 180-191.

  39. 39.Matus-Amat, P., Higgins, E.A., Barrientos, R.M., Rudy, J.W.  The role of the dorsal hippocampus in the acquisition and retrieval of context memory representations. Journal of Neuroscience, 2004, 24(10): 2431-2439.

  40. 40.Barrientos, R.M., Sprunger, D.B., Campeau, S., Higgins, E.A., Watkins, L.R., Rudy, J.W.,  Maier, S.F.  BDNF mRNA downregulation produced by social isolation is blocked by an intrahippocampal injection of IL-1 receptor antagonist (IL-1ra).  Neuroscience, 2003, 121(4): 847-853.

  41. 41.Barrientos, R.M., O’Reilly, R.C. & Rudy, J.W.  Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration.  Behavioural Brain Research, 2002, 134(1-2): 299-306.

  42. 42.Barrientos, R.M., Higgins, E.A., Sprunger, D.B., Watkins, L.R., Rudy, J.W., Maier, S.F.  Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus.  Behavioural Brain Research, 2002, 134(1-2): 291-298.

  43. 43.Rudy, J.W., Barrientos, R.M., O’Reilly, R.C.  The hippocampal formation supports conditioning to memory of a context.  Behavioral Neuroscience, 2002, 116(4): 530-538.

  44. 44.Webster, E. L., Barrientos, R.M., Contoreggi, C., Isaac, M.G., Ligier, S., Gabry K.E., Chrousos, G. P., McCarthy, E.F, Rice, K.C., Gold, P.W., Sternberg, E. M.  Corticotropin-releasing hormone (CRH) antagonist attenuates adjuvant-induced arthritis: role of CRH in peripheral inflammation.  The Journal of Rheumatology, 2002, 29(6): 1252-1261.

  45. 45.Frost, P. Barrientos, R.M., Makino, S, Wong, M.L., & Sternberg, E.M.  IL-1 receptor type I gene expression in the amygdala of inflammatory susceptible Lewis and inflammatory resistant Fischer rats.  Journal of Neuroimmunology, 2001, 121(1-2): 32-39.

  46. 46.Jafarian-Tehrani, M., Listwak, S., Barrientos, R.M., Michaud, A., Corvol, P., & Sternberg, E.M.  Exclusion of angiotensin I-converting enzyme as a candidate gene involved in exudative inflammatory resistance in F344/N rats.  Molecular Medicine, 2000, 6(4): 319-331.

  47. 47.Listwak, S*., Barrientos, R.M.*, Koike, G., Ghosh, S., Gomez, M., Misiewicz, B. & Sternberg, E.M.  Identification of a novel inflammation-protective locus in the Fischer rat.  Mammalian Genome, 1999, 10(4): 362-365. *Both authors contributed equally


Conference Abstracts (Last 5 years):

  1. 1.Barrientos, R.M., D’Angelo, H.M., Soch, A., Watkins, L.R., Maier, S.F., Spencer, S.J. High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory. Society for Neuroscience Abstracts, Washington, DC, 2017

  2. 2.Tankaka, N., Cortese, G.P., Barrientos, R.M., Maier, S.F., Patterson, S.L. Aging and an immune challenge interact to produce a prolonged, but transient reduction in hippocampal CA1 late-phase LTP and BDNF in rodent model of delirium. Society for Neuroscience Abstracts, San Diego, CA, 2016.

  3. 3.Fonken, L.K., Kitt, M.M., Gaudet, A.D., Barrientos, R.M., Watkins, L.R., & Maier, S.F. Age-associated circadian dysregulation in rats may sensitize neuroinflammatory responses. Society for Neuroscience Abstracts, San Diego, CA, 2016

  4. 4.Frank, M.G., Barrientos, R.M., Fonken, L.K., Watkins, L.R., Maier, S.F.  Acute stress induces a protracted priming of amygdalar microglia: a role for the alarmin HMGB1, CD200R and NLRP3. Society for Neuroscience Abstracts, San Diego, CA, 2016.

  5. 5.Fonken, L.K., Frank, M.G., Kitt, M.M., D'Angelo, H.M., Norden, D.M., Weber, M.D., Godbout, J.P., Barrientos, R.M., Watkins, L.R., & Maier, S.F. The alarmin HMGB1 mediates age-induced neuroinflammatory priming. Society for Behavioral Neuroendocrinology, 2016.

  6. 6.Tanaka, N., Cortese, G.P., Barrientos, R.M., Maier, S.F., Patterson, S.L. A time course of inflammation-driven changes in synaptic plasticity: the combined effects of aging and an immune challenge lead to long-lasting deficits in L-LTP in hippocampal area CA1. Society for Neuroscience Abstracts, Chicago, IL, 2015.

  7. 7.Fonken, L.K.,Kitt, M.M., Frank, M.G.,  Barrientos, R.M., Watkins, L.R., Maier, S.F. HMGB1 sensitizes microglia in the aged brain causing prolonged inflammation and cognitive impairments following infection. Society for Neuroscience Abstracts, Chicago, IL, 2015.

  8. 8.Barrientos, R.M., Kitt, M.M., Thompson, V.M., Watkins, L.R., Maier, S.F. The interaction effects of surgery and morphine treatment on neuroinflammation and cognitive decline in aged rats. Psychoneuroimmunology Research Society Abstracts, Seattle, WA, 2015.

  9. 9.Fonken, L.K., Kitt, M.M., Watkins, L.R., Barrientos, R.M., Maier, S.F. Diminished circadian rhythms in microglia may contribute to age-related neuroinflammatory sensitization. Psychoneuroimmunology Research Society Abstracts, Seattle, WA, 2015.

  10. 10.Barrientos, R.M., Thompson, V.M., Kitt, M.M., Watkins, L.R., Maier, S.F. The effects of surgery and morphine treatment on neuroinflammation and cognitive decline in aged rats. Society for Neuroscience Abstracts, Washington, DC, 2014.

  11. 11.Patterson, S.L., Cortese, G.P., Varela, J.A., Barrientos, R.M., Maier, S.F. Aging-associated immune dysregulation drives a shift in the direction of hippocampal synaptic plasticity and increases mini frequency. Society for Neuroscience Abstracts, Washington, DC, 2014.

  12. 12.Cortese, G.P., Barrientos, R.M., Maier, S.F., Patterson, S.L. Aging-associated immune dysregulation drives a shift in the direction of hippocampal synaptic plasticity and the ratio of proBDNF vs. mBDNF. Society for Neuroscience Abstracts, San Diego, CA, 2013.

  13. 13.Sobesky, J.L., Barrientos, R.M., Watkins, L.R., Maier, S.F. Interleukin-1beta mediates the hippocampal cognitive decline that occurs after 60%-fat diet consumption, which can be prevented with IL-1RA or dietary reversal. Society for Neuroscience Abstracts, San Diego, CA, 2013.

  14. 14.Barrientos, R.M., Arnold, T.H., Loram, L.C., Frank, M.G., Crysdale, N.Y., Watkins, L.R., Maier, S.F. The role of the liver in E.coli-induced memory impairments in aged rats. Psychoneuroimmunology Research Society Abstracts, Stockholm, Sweden, 2013.

  15. 15.Baartman, T.L., Swanepoel, T., Barrientos, R.M., Laburn, H.P., Dukhan, T., Mitchell, D., Harden, L.M. Dissociation between learning and memory impairment and other sickness behaviours during simulated central Mycoplasma infection in rats. Psychoneuroimmunology Research Society Abstracts, Stockholm, Sweden, 2013.

  16. 16.Barrientos, R.M., Hein, A.M., Frank, M.G., Watkins, L.R., Maier, S.F. Intracisternal interleukin-1 receptor antagonist (IL-1RA) prevents post-operative cognitive decline and neuroinflammatory response in aged rats. Society for Neuroscience Abstracts, New Orleans, LA, 2012.

  17. 17.Frank, M.G., Barrientos, R.M., Thompson, B.M., Weber, M.D., Watkins, L.R., Maier, S.F. IL-1RA injected ICM confers extended prophylaxis against LPS-induced neuroinflammatory and sickness responses. Society for Neuroscience Abstracts, New Orleans, LA, 2012.

  18. 18.Hartzell, A.L, Barrientos, R.M., Hoang, L.T., Lister, J.P., Maier, S.F., Barnes, C.A. The effect of peripheral E. coli on behaviorally-induced Arc expression patterns in hippocampal granule cells. Society for Neuroscience Abstracts, New Orleans, LA,  2012.

  19. 19.Chapman, T.R., Cortese, G.P., Barrientos, R.M., Engelberg, E.M., Maier, S.F., Patterson, S.L. Interactions of aging, inflammation, and synaptic function: A peripheral immune challenge reduces the contribution of L-type calcium channels to hippocampal long-term potentiation. Society of Neuroscience Abstracts, New Orleans, LA, 2012.

  20. 20.Cortese, G.P., Chapman, T.R., Barrientos, R.M., Maier, S.F., Patterson, S.L. The combination of aging and a peripheral immune challenge enhances hippocampal LTD and promotes proBDNF-p75 interactions. Society of Neuroscience Abstracts, New Orleans, LA, 2012.

  21. 21.Barrientos, R.M., Crysdale, N.Y., Hale, M.W., Amat, J., Frank, M.G., Stamper, C.E., Hennessey, P.A., Watkins, L.R., Spencer, R.L., Lowry, C.A., Maier, S.F. Characterization of the neuroendocrine system in healthy aged rats. Psychoneuroimmunolgy Research Society Abstracts, San Diego, CA, 2012.